The author shows that when Giordano Bruno takes up again the Heraclitus’ philosophical vision, develops along with him a complex perspective of nature. That is to say, he recognizes the unity or integration of the diversity of elements that conforms it, without denying its divergence and opposition. Through the revision of the unity of opposites and the conception of nature as one and multiple, it is shown the proposal of Heraclitus and Bruno: that the reason resembles the mode of being of the nature, in the search for the integra-tion of the diverse.